Astronautics
- Orion (spacecraft), NASA's Space Shuttle replacement
- Orion Lite, a proposed stripped-down version of the Orion spacecraft
- Orion, the Apollo Lunar Module used in the Apollo 16 mission
- Orion 1 and Orion 2 Space Observatories
- Orion (U.S. rocket)
- Orion (Argentine rocket)
- Orion, a series of rocket motors used in the Pegasus rockets
- Project Orion (nuclear propulsion), a project of nuclear pulse propulsion utilizing atomic bomb explosions
- Project Orion, a project to build a laser broom for the International Space Station
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