Opioid Antagonist - Depersonalization Disorder

Depersonalization Disorder

Naloxone and naltrexone have both been studied for the treatment of depersonalization disorder. In a 2001 study with naloxone, three of fourteen patients lost their depersonalization symptoms entirely, and seven showed marked improvement. The findings of a 2005 naltrexone study were slightly less promising, with an average of a 30% reduction of symptoms, as measured by 3 validated dissociation scales. The more dramatic result of naloxone versus naltrexone is suspected to be due to different endogenous opioid receptor selectivity in naloxone, which is better suited to individuals suffering from depersonalization disorder.