NUF2

Identifiers Symbols NUF2; CDCA1; CT106; NUF2R External IDs OMIM: 611772 MGI: 1914227 HomoloGene: 40205 GeneCards: NUF2 Gene

Gene Ontology
Molecular function	• molecular_function • protein binding
Cellular component	• chromosome, centromeric region • condensed chromosome kinetochore • nucleus • cytosol • Ndc80 complex
Biological process	• M phase of mitotic cell cycle • mitotic anaphase • mitotic prometaphase • mitotic cell cycle • chromosome segregation • cell division
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 83540 66977 Ensembl ENSG00000143228 ENSMUSG00000026683 UniProt Q9BZD4 Q99P69 RefSeq (mRNA) NM_031423 NM_023284 RefSeq (protein) NP_113611 NP_075773 Location (UCSC) Chr 1:
163.24 – 163.33 Mb Chr 1:
169.5 – 169.53 Mb PubMed search

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.