Nucleoside Deoxyribosyltransferase

In enzymology, a nucleoside deoxyribosyltransferase (EC 2.4.2.6) is an enzyme that catalyzes the chemical reaction

2-deoxy-D-ribosyl-base₁ + base₂ 2-deoxy-D-ribosyl-base₂ + base₁

Thus, the two substrates of this enzyme are 2-deoxy-D-ribosyl-base₁ and base₂, whereas its two products are 2-deoxy-D-ribosyl-base₂ and base₁.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase. Other names in common use include purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl, transferase, deoxyribose transferase, nucleoside trans-N-deoxyribosylase, trans-deoxyribosylase, trans-N-deoxyribosylase, trans-N-glycosidase, nucleoside deoxyribosyltransferase I (purine nucleoside:purine, deoxyribosyltransferase: strictly specific for transfer between, purine bases), nucleoside deoxyribosyltransferase II . This enzyme participates in pyrimidine metabolism.