NT5C

Identifiers Symbols NT5C; DNT; DNT1; P5N2; PN-I; PN-II; UMPH2; cdN; dNT-1 External IDs OMIM: 191720 MGI: 1354954 HomoloGene: 8745 GeneCards: NT5C Gene EC number 3.1.3.5

Gene Ontology
Molecular function	• nucleotidase activity • 5'-nucleotidase activity • pyrimidine nucleotide binding • metal ion binding
Cellular component	• nucleus • cytoplasm • mitochondrion • cytosol
Biological process	• purine nucleobase metabolic process • purine nucleotide catabolic process • pyrimidine nucleobase metabolic process • pyrimidine deoxyribonucleotide catabolic process • dephosphorylation • small molecule metabolic process • pyrimidine nucleoside catabolic process • nucleobase-containing small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 30833 50773 Ensembl ENSG00000125458 ENSMUSG00000020736 UniProt Q8TCD5 Q9JM14 RefSeq (mRNA) NM_001252377 NM_015807 RefSeq (protein) NP_001239306 NP_056622 Location (UCSC) Chr 17:
73.13 – 73.13 Mb Chr 11:
115.49 – 115.49 Mb PubMed search

5'(3')-deoxyribonucleotidase, cytosolic type is an enzyme that in humans is encoded by the NT5C gene.

Pyrimidine 5-prime nucleotidase (P5N; EC 3.1.3.5), also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1; MIM 606224) and type II (UMPH2).