In Children
Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) was first reported in 1983. It is currently the primary form of liver disease among children. NAFLD has been associated with the metabolic syndrome, which is a cluster of risk factors that contribute to the development of cardiovascular disease and type 2 diabetes mellitus. Studies have demonstrated that abdominal obesity and insulin-resistance in particular are thought to be key contributors to the development of NAFLD. Because obesity is becoming an increasingly common problem worldwide, the prevalence of NAFLD has been increasing concurrently. Moreover, boys are more likely to be diagnosed with NAFLD than girls with a ratio of 2:1. Studies have suggested that progression toward a more advance stage of disease among children is dependent on age and presence of obesity. This finding is consistent with previous studies in adults demonstrating the same association between age and obesity, and liver fibrosis. Early diagnosis of NAFLD in children may help prevent the development of liver disease during adulthood. This is challenging as most children with NAFLD are asymptomatic with few showing abdominal pain. Currently, liver biopsy is considered the gold standard for diagnosing NAFLD. However, this method is invasive, costly and bears greater risk for children, and noninvasive screening and diagnosing methods would have significant public health implications for children with NAFLD. The only treatment shown to be truly effective in childhood NAFLD is weight loss.
Read more about this topic: Non-alcoholic Fatty Liver Disease
Famous quotes containing the word children:
“Awareness of having better things to do with their lives is the secret to immunizing our children against false values—whether presented on television or in “real life.” The child who finds fulfillment in music or reading or cooking or swimming or writing or drawing is not as easily convinced that he needs recognition or power or some “high” to feel worthwhile.”
—Polly Berrien Berends (20th century)
“A woman who writes feels too much,
those trances and portents!
As if cycles and children and islands
weren’t enough; as if mourners and gossips
and vegetables were never enough.”
—Anne Sexton (1928–1974)