Characteristics
- No activity of T cell, B cell and NK cell
- Reduced complementary activities
- Dysfunction of macrophage
- Dysfunction of dendritic cell
- No leakiness: no incidence of T, B cells with aging
- No incidence of lymphoma
NOG mouse has multiple immunodeficiencies that are principally derived from three strains of mice: 1) NOD/Shi inbred strain, 2) SCID, 3) IL-2Rγnull. These include:
- Reduced innate immunity derived from a NOD inbred strain, which involves a macrophage dysfunction, and a defect of complement hemolytic activity and reduced NK activity. The NOD/Shi inbred strain was first discovered by Makino et al. as autoimmune non-obese-type diabetes mice.
- Lack of functional T and B cells that is derived from a mutation of protein kinase (Prkdc: protein kinase, DNA activated, catalytic polypeptide), which is the causative gene of the scid mutation
- Lack of NK cells, dendritic cell dysfunctions, and other unknown deficiencies due to inactivation of the IL-2Rγ gene.
Read more about this topic: NOG Mouse