NME1

NME1

Identifiers Symbols NME1; AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1 External IDs OMIM: 156490 MGI: 97355 HomoloGene: 128514 ChEMBL: 2159 GeneCards: NME1 Gene EC number 2.7.4.6

Gene Ontology
Molecular function	• magnesium ion binding • RNA polymerase II regulatory region sequence-specific DNA binding • single-stranded DNA binding • deoxyribonuclease activity • nucleoside diphosphate kinase activity • protein binding • ATP binding • GTP binding • intermediate filament binding • protein kinase binding • identical protein binding • gamma-tubulin binding • ribosomal small subunit binding
Cellular component	• nucleus • cytoplasm • centrosome • cytosol • membrane • perinuclear region of cytoplasm
Biological process	• negative regulation of myeloid leukocyte differentiation • GTP biosynthetic process • UTP biosynthetic process • CTP biosynthetic process • endocytosis • negative regulation of cell proliferation • negative regulation of gene expression • positive regulation of neuron projection development • response to amine stimulus • nucleobase-containing small molecule interconversion • hippocampus development • response to testosterone stimulus • cellular response to drug • regulation of apoptotic process • positive regulation of DNA binding • small molecule metabolic process • positive regulation of epithelial cell proliferation • response to cAMP • nucleobase-containing small molecule metabolic process • cellular response to glucose stimulus • cellular response to fatty acid
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 4830 18102 Ensembl ENSG00000239672 ENSMUSG00000037601 UniProt P15531 P15532 RefSeq (mRNA) NM_000269 NM_008704 RefSeq (protein) NP_000260 NP_032730 Location (UCSC) Chr 17:
49.23 – 49.24 Mb Chr 11:
93.96 – 93.97 Mb PubMed search

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis suppressor.

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.