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- Rachel Nichols (actress)
- Rachel Nichols (reporter)
- Red Nichols (1905–1965), jazz cornettist
- Reid Nichols (1958 - ), American former Major League Baseball outfielder, now Farm Director/Director of Player Development for the Milwaukee Brewers
- Robert Nichols (poet), English poet
- Robert Nichols (Texas politician), Texas State Senator
- Rob Nichols
- Roger Nichols (songwriter)
- Roger Nichols (recording engineer)
- Roy Nichols
- Ross Nichols
- Ruth Nichols, Canadian author
- Ruth Rowland Nichols (1901–1960), aviator
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