Neutrophil Cytosolic Factor 2

Identifiers Symbols NCF2; NCF-2; NOXA2; P67-PHOX; P67PHOX External IDs OMIM: 608515 MGI: 97284 HomoloGene: 374 GeneCards: NCF2 Gene

Gene Ontology
Molecular function	• protein binding • protein C-terminus binding • electron carrier activity • Rac GTPase binding
Cellular component	• acrosomal vesicle • nucleolus • cytoplasm • cytosol • phagolysosome • NADPH oxidase complex
Biological process	• antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • superoxide metabolic process • cellular defense response • aging • response to glucose stimulus • response to activity • response to lipopolysaccharide • response to progesterone stimulus • cellular response to hormone stimulus • response to laminar fluid shear stress • response to drug • superoxide anion generation • antigen processing and presentation of exogenous peptide antigen via MHC class I • positive regulation of neuron apoptotic process • innate immune response • respiratory burst • positive regulation of blood pressure • interaction with host • response to hyperoxia • phagosome maturation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4688 17970 Ensembl ENSG00000116701 ENSMUSG00000026480 UniProt P19878 O70145 RefSeq (mRNA) NM_000433 NM_010877 RefSeq (protein) NP_000424 NP_035007 Location (UCSC) Chr 1:
183.52 – 183.56 Mb Chr 1:
152.81 – 152.84 Mb PubMed search

Neutrophil cytosol factor 2 is a protein that in humans is encoded by the NCF2 gene.

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.