Neurotrophin - Structure

Structure

NGF is a protein of about 120 residues that is cleaved from a larger precursor molecule. It contains six cysteines all involved in intrachain disulfide bonds. A schematic representation of the structure of NGF is shown below:

+------------------------+ | | | | xxxxxxCxxxxxxxxxxxxxxxxxxxxxCxxxxCxxxxxCxxxxxxxxxxxxxCxCxxxx | | | | +--------------------------|-----+ | +---------------------+

where 'C': conserved cysteine involved in a disulfide bond.

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