Neuropilin 1

Neuropilin 1

Identifiers Symbols NRP1; BDCA4; CD304; NP1; NRP; VEGF165R External IDs OMIM: 602069 MGI: 106206 HomoloGene: 2876 ChEMBL: 5174 GeneCards: NRP1 Gene

Gene Ontology
Molecular function	• vascular endothelial growth factor-activated receptor activity • protein binding • heparin binding • coreceptor activity • semaphorin receptor activity • growth factor binding • cytokine binding • metal ion binding
Cellular component	• semaphorin receptor complex • extracellular region • cytosol • neurofilament • plasma membrane • cell surface • integral to membrane • growth cone • cytoplasmic vesicle • neuronal cell body • receptor complex
Biological process	• patterning of blood vessels • positive regulation of endothelial cell proliferation • cell adhesion • signal transduction • cell-cell signaling • axon guidance • axonal fasciculation • heart development • response to wounding • organ morphogenesis • positive regulation of endothelial cell migration • positive regulation of smooth muscle cell migration • dendrite development • trigeminal nerve morphogenesis • cellular response to hepatocyte growth factor stimulus • endothelial cell chemotaxis • platelet-derived growth factor receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • hepatocyte growth factor receptor signaling pathway • sympathetic nervous system development • negative regulation of axon extension involved in axon guidance • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of cytokine activity • regulation of vesicle-mediated transport • dichotomous subdivision of terminal units involved in salivary gland branching • semaphorin-plexin signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8829 18186 Ensembl ENSG00000099250 ENSMUSG00000025810 UniProt O14786 P97333 RefSeq (mRNA) NM_001024628 NM_008737 RefSeq (protein) NP_001019799 NP_032763 Location (UCSC) Chr 10:
33.47 – 33.63 Mb Chr 8:
128.36 – 128.51 Mb PubMed search

Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. This is one of two human neuropilins.

NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.