Treatment
Treat any underlying cause, allow the patient to drink as much as required. Correct metabolic abnormalities. The first line of treatment is hydrochlorothiazide and amiloride. Consider a low-salt and low-protein diet.
In nephrogenic Diabetes Inspidus caused by lithium (seen in bipolar patients for example), K-sparing diuretics such as amiloride would be used. The goal in this case is to excrete lithium. Using Hydrochlorothiazide in this case would increase aldosterone, which would lead to increased sodium retention (and lithium as well).
Read more about this topic: Nephrogenic Diabetes Insipidus
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—C. John Sommerville (20th century)