Negative selection may refer to:
- In biology:
- Negative selection (natural selection), in natural selection it refers to the selective removal of rare alleles that are deleterious
- Negative selection (artificial selection), in artificial selection it refers to where negative, rather than positive, traits of a species are selected for
- In politics:
- Negative selection (politics), is a process that occurs in rigid hierarchies, most notably dictatorships
- In immunology:
- Negative selection (immunology) T-cells that recognize self MHC molecules (and peptides) with high affinity are deleted from the repertoire of cells. Central tolerance is produced. Avoids auto-immunity. Occurs after positive selection.
Famous quotes containing the words negative and/or selection:
“The negative cautions of science are never popular. If the experimentalist would not commit himself, the social philosopher, the preacher, and the pedagogue tried the harder to give a short- cut answer.”
—Margaret Mead (1901–1978)
“Every writer is necessarily a critic—that is, each sentence is a skeleton accompanied by enormous activity of rejection; and each selection is governed by general principles concerning truth, force, beauty, and so on.... The critic that is in every fabulist is like the iceberg—nine-tenths of him is under water.”
—Thornton Wilder (1897–1975)