Nasal Administration - Drugs For Nasal Administration

Drugs For Nasal Administration

Nasal sprays for local effect are quite common. Several antimigraine drugs are also currently administered by nasal administration because a fast effect is desired and oral administration can be prohibited by nausea. Peptide drugs (hormone treatments) are also available as nasal sprays, in this case to avoid drug degradation after oral administration. The peptide analogue desmopressin is, for example, available for both nasal and oral administration. The bioavailability of the commercial tablet is 0.1% while that of the nasal spray is 3-5% according to the SPC (Summary of Product Characteristics). Other potential drug candidates for nasal administration include anaesthetics, antiemetics and sedatives that all benefit from a fast onset of effect.