Causes
Trauma, vascular problems, venoms, malignant hyperthermia, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys.
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute renal insufficiency.
Other causes of myoglobinuria include:
- McArdle's disease
- Phosphofructokinase deficiency
- Carnitine palmitoyltransferase II deficiency
- malignant hyperthermia
Read more about this topic: Myoglobinuria