People
- Andrew Murdock, American record producer
- Andrew G. Murdock, botanist whose official abbreviation is "Murdock", who described the fern genus Ptisana
- Colin Murdock, Northern Irish footballer
- D.M. Murdock, better known by pen name Acharya S, author and proponent of the Christ myth theory
- David H. Murdock, American businessman
- Deroy Murdock, American syndicated columnist
- Eric Murdock, retired American professional basketball player
- George Peter Murdock, American anthropologist who collected cultural traits for comparative purposes
- George Murdock, American actor
- Ian Murdock, founder and former leader of the Debian GNU/Linux Distribution
- Joseph Murdock (disambiguation), various people
- Kirk Radomski (known to players as Murdock), former New York Mets employee
- Mike Murdock, American televangelist and pastor
- Orrice Abram Murdock, Jr., United States Representative and Senator from Utah
- Roger E. Murdock, LAPD Chief
- Sharon Murdock, Canadian politician
- Shirley Murdock, American R&B singer
- William Murdock, 18th century US politician
- William Murdoch, also spelled Murdock, early 19th century Scottish engineer
- Fictional
- Murdock, the fictional main antagonist in Carland Cross
- Buz Murdock, fictional character
- H. M. Murdock ("Howling Mad Murdock"), character played by the actor Dwight Schultz in the 1980s TV series The A-Team
- Roger Murdock, character from Airplane!, played by Kareem Abdul-Jabbar
- Buck Murdock, character from Airplane II: The Sequel, played by William Shatner
- Matt Murdock, fictional character, aka Daredevil (Marvel Comics)
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