MSX1
Gene Ontology | |
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Molecular function | • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity • p53 binding • sequence-specific DNA binding |
Cellular component | • nucleus • transcription factor complex |
Biological process | • negative regulation of transcription from RNA polymerase II promoter • cell morphogenesis • in utero embryonic development • epithelial to mesenchymal transition involved in endocardial cushion formation • muscle organ development • negative regulation of cell proliferation • anterior/posterior pattern specification • mesenchymal cell proliferation • signal transduction involved in regulation of gene expression • apoptotic nuclear changes • negative regulation of cell growth • positive regulation of BMP signaling pathway • forebrain development • midbrain development • protein localization to nucleus • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • embryonic nail plate morphogenesis • middle ear morphogenesis • odontogenesis of dentin-containing tooth • regulation of odontogenesis • positive regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of transcription from RNA polymerase II promoter • stem cell differentiation • protein stabilization • negative regulation of striated muscle cell differentiation • palate development • face morphogenesis • bone morphogenesis • cartilage morphogenesis • mammary gland epithelium development • BMP signaling pathway involved in heart development • negative regulation of transcription regulatory region DNA binding |
Sources: Amigo / QuickGO |
4.86 – 4.87 Mb
37.82 – 37.82 Mb
Msh homeobox 1, also known as MSX1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development.
Read more about MSX1: Function, Interactions