Msh Homeobox 2

Msh Homeobox 2

Identifiers Symbols MSX2; CRS2; FPP; HOX8; MSH; PFM; PFM1 External IDs OMIM: 123101 MGI: 97169 HomoloGene: 1837 GeneCards: MSX2 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • transcription cofactor activity • protein binding • sequence-specific DNA binding • transcription regulatory region DNA binding
Cellular component	• nucleus • transcription factor complex • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • osteoblast differentiation • chondrocyte development • osteoblast development • outflow tract septum morphogenesis • epithelial to mesenchymal transition involved in endocardial cushion formation • endochondral bone growth • transcription, DNA-dependent • negative regulation of cell proliferation • anterior/posterior pattern specification • signal transduction involved in regulation of gene expression • positive regulation of BMP signaling pathway • negative regulation of CREB transcription factor activity • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • wound healing, spreading of epidermal cells • embryonic nail plate morphogenesis • anagen • positive regulation of apoptotic process • negative regulation of apoptotic process • negative regulation of fat cell differentiation • negative regulation of keratinocyte differentiation • positive regulation of osteoblast differentiation • negative regulation of transcription, DNA-dependent • stem cell differentiation • positive regulation of catagen • bone trabecula formation • cranial suture morphogenesis • frontal suture morphogenesis • branching involved in mammary gland duct morphogenesis • BMP signaling pathway involved in heart development • enamel mineralization • cellular response to growth factor stimulus • cellular response to estradiol stimulus • negative regulation of transcription regulatory region DNA binding
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4488 17702 Ensembl ENSG00000120149 ENSMUSG00000021469 UniProt P35548 Q03358 RefSeq (mRNA) NM_002449 NM_013601 RefSeq (protein) NP_002440 NP_038629 Location (UCSC) Chr 5:
174.15 – 174.16 Mb Chr 13:
53.47 – 53.47 Mb PubMed search

Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.

This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.