Mrs. Frisby and The Rats of NIMH

Mrs. Frisby and the Rats of NIMH is a 1971 children's book by Robert C. O'Brien. Illustrated by Zena Bernstein, it won the 1972 Newbery Medal. A film adaptation, The Secret of NIMH, was released in 1982.

The novel relates the plight of a widowed field mouse, Mrs. Frisby, who seeks the aid of a group of former laboratory rats in rescuing her home from destruction by a farmer's plow, and of the history of the rats' escape from the laboratory and development of a literate and technological society.

The work was inspired by the research of Dr. John B. Calhoun on mice and rat population dynamics at the National Institute of Mental Health.

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