Contraindications
The following conditions are relative contraindications for morphine:
- acute respiratory depression
- renal failure (due to accumulation of the metabolites morphine-3-glucuronide and morphine-6-glucuronide)
- chemical toxicity (potentially lethal in low tolerance subjects)
- raised intracranial pressure, including head injury (risk of worsening respiratory depression)
- Biliary colic.
Although it has previously been thought that morphine was contraindicated in acute pancreatitis, a review of the literature shows no evidence for this.
Read more about this topic: Morphine