Mohamed Omer (or similar) may refer to:
- Mohammed Omer, Palestinian journalist, winner of the 2007 Martha Gellhorn Prize for Journalism
- Mohamed Omer (Eritrean politician), interim foreign minister after the death of Ali Said Abdella
- Mohamed Omer (footballer), football player from the United Arab Emirates
- Mohamed Salih Omer (1934–1969), Sudanese politician
- Mohammad Omar (prince), half-brother of the emir of Afghanistan, circa 1900, see 1901 in Afghanistan
- Mohammad Omar (musician) (1905–1980), Afghani musician
- Mohammed Omar (born 1959), leader of the Taliban
- Engineer Mohammad Omar, Governor of Kunduz Province, Afghanistan, circa 2009
- Mohamed Omar (born 1976), Swedish poet
- Mohammed Omar (child detainee) (born 1986), former Guantanamo captive, profiled by the McClatchy News Service