Contraindications and Cautions
Contraindications:
The combination of moclobemide with prescription or over the counter sympathomimetic drugs is not recommended due to the potential of significant drug interactions.
- Hypersensitivity to moclobemide
- States of severe confusion
- While moclobemide or the irreversible MAO-B selective inhibitor selegiline taken alone has very little pressor effect, and requires no dietry restriction, the combination of seligiline with moclobemide leads to a significant enhancement of the pressor effect and such a combination requires dietary restriction of foods containing high amounts of tyramine. The combination of moclobemide and a reversible MAO-B inhibitor requires tyramine dietary restrictions.
- Concomitant treatment with clomipramine
- Combination treatment with pethidine (Interaction may be fatal)
- Combination treatment with dextromethorphan
- Pediatric patients (no sufficient data exists)
Caution:
Using moclobemide in combination with drugs which enhance serotonin require caution. Individuals who have liver impairment may require dose reduction of about one half or one third.
- Concomitant treatment with SSRIs may lead to a serotonin syndrome. After termination of SSRI treatment, moclobemide should not be used until four to five half-lives of the SSRI have elapsed (five weeks in the case of fluoxetine and two weeks otherwise).
- Patients with schizophrenia (psychosis may exacerbate, longterm treatment with neuroleptics should be continued.)
- Patients with hyperthyroidism (overfunction of the thyroid gland) and phaeochromocytoma. Hypertensive reactions are possible, therefore treatment with moclobemide cannot be recommended.
- Patients with uncontrolled hypertension
- Patients with bipolar disorder.
Read more about this topic: Moclobemide