MMP8

MMP8

Identifiers Symbols MMP8; CLG1; HNC; MMP-8; PMNL-CL External IDs OMIM: 120355 MGI: 1202395 HomoloGene: 22482 ChEMBL: 4588 GeneCards: MMP8 Gene EC number 3.4.24.34

Gene Ontology
Molecular function	• metalloendopeptidase activity • serine-type endopeptidase activity • calcium ion binding • zinc ion binding
Cellular component	• extracellular region • proteinaceous extracellular matrix • extracellular space
Biological process	• proteolysis • extracellular matrix disassembly • extracellular matrix organization • collagen catabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4317 17394 Ensembl ENSG00000118113 ENSMUSG00000005800 UniProt P22894 O70138 RefSeq (mRNA) NM_002424 NM_008611 RefSeq (protein) NP_002415 NP_032637 Location (UCSC) Chr 11:
102.58 – 102.6 Mb Chr 9:
7.56 – 7.57 Mb PubMed search

Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. In humans, the MMP-8 protein is encoded by the MMP8 gene.