Junctions
From east to west
- U.S. Highway 278
- Mississippi Highway 25
- U.S. Highway 45
- Mississippi Highway 145
- U.S. Highway 45 Alternate
- Mississippi Highway 47
- Natchez Trace Parkway
- Mississippi Highway 389
- Mississippi Highway 15
- Mississippi Highway 341
- Mississippi Highway 9
- Mississippi Highway 333
- U.S. Highway 51
- Mississippi Highway 7 / Interstate 55 ( splits eastbound, joins westbound)
- Mississippi Highway 35 ( splits eastbound, joins westbound)
( splits westbound, joins eastbound)
( splits westbound, joins eastbound)
- U.S. Highway 49E
- U.S. Highway 49W / Mississippi Highway 3
- U.S. Highway 61 / U.S. Highway 278
- Mississippi Highway 1
Read more about this topic: Mississippi Highway 8