Present)
| 1. | Arthur Laing | October 1, 1966 - April 20, 1968 | Cabinet of Prime Minister Lester Pearson |
| April 20, 1968 - July 5, 1968 | Cabinet of Prime Minister Pierre Trudeau | ||
| 2. | Jean Chrétien | July 5, 1968 - August 7, 1974 | |
| 3. | J. Judd Buchanan | August 8, 1974 - September 13, 1976 | |
| 4. | Warren Allmand | September 14, 1976 - September 15, 1977 | |
| 5. | James Hugh Faulkner | September 16, 1977 - June 3, 1979 | |
| 6. | Jake Epp | June 4, 1979 - March 2, 1980 | Cabinet of Prime Minister Joe Clark |
| 7. | John Munro | March 3, 1980 - June 29, 1984 | Cabinet of Prime Minister Pierre Trudeau |
| 8. | Doug Frith | June 30, 1984 - September 16, 1984 | Cabinet of Prime Minister John Turner |
| 9. | David Crombie | September 17, 1984 - June 29, 1986 | Cabinet of Prime Minister Brian Mulroney |
| 10. | Bill McKnight | June 30, 1986 - January 29, 1989 | |
| 11. | Pierre Cadieux | January 30, 1989 - February 22, 1990 | |
| 12. | Tom Siddon | February 23, 1990 - June 24, 1993 | |
| 13. | Pauline Browes | June 25, 1993 - November 3, 1993 | Cabinet of Prime Minister Kim Campbell |
| 14. | Ron Irwin | November 4, 1993 - June 10, 1997 | Cabinet of Prime Minister Jean Chrétien |
| 15. | Jane Stewart | June 11, 1997 - August 2, 1999 | |
| 16. | Bob Nault | August 3, 1999 - December 11, 2003 | |
| 17. | Andy Mitchell | December 12, 2003 - July 19, 2004 | Cabinet of Prime Minister Paul Martin |
| 18. | Andy Scott | July 20, 2004 - February 5, 2006 | |
| 19. | Jim Prentice | February 6, 2006 - August 14, 2007 | Cabinet of Prime Minister Stephen Harper |
| 20. | Chuck Strahl | August 14, 2007 - August 6, 2010 | |
| 21. | John Morris Duncan | August 6, 2010 – present |
Prior to 1966, responsibilities for the Indian Affairs portion of this portfolio fell under the Minister of Citizenship and Immigration (List), and the Northern Development portion under the Minister of Northern Affairs and National Resources (List).
On May 18, 2011, the Minister adopted the working title "Minister of Aboriginal Affairs and Northern Development". However, pursuant to section 2 of the Department of Indian Affairs and Northern Development Act he remains, for legal purposes, the "Minister of Indian Affairs and Northern Development".
Read more about this topic: Minister Of Aboriginal Affairs And Northern Development (Canada), Ministers of Indian Affairs and Northern Development (1966