The Riemann Hypothesis
The Riemann hypothesis is that all nontrivial zeros of the analytical continuation of the Riemann zeta function have a real part of 1/2. A proof or disproof of this would have far-reaching implications in number theory, especially for the distribution of prime numbers. This was Hilbert's eighth problem, and is still considered an important open problem a century later.
The official statement of the problem was given by Enrico Bombieri.
Read more about this topic: Millennium Problems
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“It is a good morning exercise for a research scientist to discard a pet hypothesis every day before breakfast. It keeps him young.”
—Konrad Lorenz (19031989)