METAP2

METAP2

Identifiers Symbols METAP2; MAP2; MNPEP; p67; p67eIF2 External IDs OMIM: 601870 MGI: 1929701 HomoloGene: 4981 ChEMBL: 3922 GeneCards: METAP2 Gene EC number 3.4.11.18

Gene Ontology
Molecular function	• aminopeptidase activity • metalloexopeptidase activity • metal ion binding
Cellular component	• cytoplasm
Biological process	• proteolysis • protein processing • peptidyl-methionine modification • N-terminal protein amino acid modification
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10988 56307 Ensembl ENSG00000111142 ENSMUSG00000036112 UniProt P50579 O08663 RefSeq (mRNA) NM_006838 NM_019648 RefSeq (protein) NP_006829 NP_062622 Location (UCSC) Chr 12:
95.87 – 95.91 Mb Chr 10:
93.86 – 93.9 Mb PubMed search

Methionine aminopeptidase 2 is an enzyme that in humans is encoded by the METAP2 gene.

Methionine aminopeptidase 2, a member of the dimetallohydrolase family, is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine residues from nascent proteins.

• peptide-methionine peptide + methionine

MetAP2 is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. Furthermore, MetAP2 is of particular interest because the enzyme plays a key role in angiogenesis, the growth of new blood vessels, which is necessary for the progression of diseases including solid tumor cancers and rheumatoid arthritis. MetAP2 is also the target of two groups of anti-angiogenic natural products, ovalicin and fumagillin, and their analogs.