Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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“Now the appearance of the glory of the LORD was like a devouring fire on the top of the mountain in the sight of the people of Israel.”
—Bible: Hebrew, Exodus 24:17.