Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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“Men of all professions affect such an air and appearance as to seem to be what they wish to be believed to be—so that one might say the whole world is made up of nothing but appearances.”
—François, Duc De La Rochefoucauld (1613–1680)