Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.
Mature mRNA is also called "mature transcript", "mature RNA" or "mRNA".
The production of a mature mRNA molecule occurs in 3 steps:
- During capping, a 7-methylguanosine residue is attached to the 5'-terminal end of the primary transcripts. This is otherwise known as the GTP or 5' Cap, and is used for the stability and attachment point for ribosomes.
- In polyadenylation, a poly-adenosine tail of about 200 adenylate residues is added by a nuclear polymerase post-transcriptionally. This is known as a Poly-A tail and is used for stability and guidance, so that the mRNA can exit the nucleus and find the ribosome.
- RNA splicing removes the non-coding RNA introns leaving behind the coding sequences exons, which are then spliced and joined together to form the final mRNA.
Famous quotes containing the words mature and/or messenger:
“Young people love what is interesting and odd, no matter how true or false it is. More mature minds love what is interesting and odd about truth. Fully mature intellects, finally, love truth, even when it appears plain and simple, boring to the ordinary person; for they have noticed that truth tends to reveal its highest wisdom in the guise of simplicity.”
—Friedrich Nietzsche (1844–1900)
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—Paul Nash (1889–1946)