Matrix Metallopeptidase 12

Matrix Metallopeptidase 12

Identifiers Symbols MMP12; HME; ME; MME; MMP-12 External IDs OMIM: 601046 MGI: 97005 HomoloGene: 20547 ChEMBL: 4393 GeneCards: MMP12 Gene EC number 3.4.24.65

Gene Ontology
Molecular function • endopeptidase activity
• metalloendopeptidase activity
• calcium ion binding
• zinc ion binding
Cellular component • proteinaceous extracellular matrix
Biological process • proteolysis
• wound healing, spreading of epidermal cells
• positive regulation of epithelial cell proliferation involved in wound healing
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4321 17381 Ensembl ENSG00000110347 ENSMUSG00000049723 UniProt P39900 P34960 RefSeq (mRNA) NM_002426 NM_008605 RefSeq (protein) NP_002417 NP_032631 Location (UCSC) Chr 11:
102.73 – 102.75 Mb Chr 9:
7.34 – 7.37 Mb PubMed search

Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene.

Read more about Matrix Metallopeptidase 12:  Function, Clinical Significance

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