Junction List
| County | Location | Mile | Roads intersected | Notes |
|---|---|---|---|---|
| Worcester | West Boylston | 0.00 | Route 12 | Western terminus of Route 110. To Route 140, via Route 12 South. |
| Clinton | 5.5 | Route 62 east / Route 70 south | Beginning of triple concurrency | |
| 5.8 | Route 62 west / Route 70 north | End of triple concurrency | ||
| Bolton | 9.4 | Route 117 | ||
| Harvard | 14.4 | Route 111 south | Beginning of concurrency with Route 111 | |
| 16.0 | Route 2 | Route 2 Exits 38A-B | ||
| Middlesex | Ayer | 18.1 | Route 2A west / Route 111 north | End of concurrency with Route 111 Beginning of concurrency with Route 2A |
| Littleton | 22.6 | I-495 | I-495 Exit 30 | |
| 23.9 | Route 2A east / Route 119 | End of concurrency with Route 2A To I-495 via Route 119 North |
||
| Westford | 25.3 | Route 225 west | Beginning of concurrency with Route 225 | |
| 25.6 | Route 225 east | End of concurrency with Route 225. | ||
| 26.8 | Boston Road | To I-495 via Boston Road northbound | ||
| Chelmsford | 31.2 | Route 4 / Route 129 west | Brief concurrency between Routes 4 and 110 Western terminus of Route 129 To Route 27 via Route 4 south |
|
| 31.8 | I-495 | I-495 Exit 34 | ||
| 32.8 | US 3 | US 3 Exit 31 | ||
| Lowell | 34.7 | Route 3A | Brief concurrency between Routes 3A/110 To Lowell Connector via Route 3A south |
|
| 35.7 | Route 38 south / Route 133 east | Beginning of concurrency with Route 38 Western terminus of Route 133 |
||
| 36.1 | Route 38 north | End of concurrency with Route 38 at rotary interchange above VFW Parkway | ||
| Dracut | No intersections, except with residential streets | |||
| Essex | Methuen | 43.0 | I-93 / Route 113 west | I-93 Exit 46 Brief concurrency between Routes 110 and 113 |
| Lawrence | 45.3 | Route 28 | To Route 114 north, via Route 28 South | |
| Methuen | 47.9 | I-495 | I-495 Exit 46 | |
| 49.3 | Route 113 west | Beginning of concurrency with Route 113 | ||
| Haverhill | 52.0 | I-495 | I-495 Exit 49 | |
| 54.3 | Route 113 east | End of concurrency with Route 113 | ||
| 54.6 | Route 97 | |||
| 55.0 | Route 125 | Brief concurrency between Routes 110 and 125 | ||
| 56.0 | Route 108 north | Southern terminus of Route 108; To NH 108 | ||
| 57.0 | I-495 | I-495 Exit 52 | ||
| Amesbury | 64.1 | Route 150 | To I-495 Exit 54, via Route 150 South | |
| 65.0 | I-495 south | I-495 Exit 55: Northbound exit to Route 110 East Southbound entrance from Route 110 West only |
||
| 65.9 | I-95 | I-95 Exits 58A-B | ||
| Salisbury | 69.24 | US 1 | Eastern terminus of Route 110. To Route 1A via US 1 North. |
Read more about this topic: Massachusetts Route 110
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