Mario Martinez may refer to:
- Mario Martinez (weightlifter) (born 1957), Olympic weightlifter for the United States
- Mario Aburto Martínez (born 1970), Mexican assassin
- Mario Martinez (painter) (born 1953), contemporary abstract painter
- Mario Martinez (tennis) (born 1961), Bolivian tennis player
- Mario Martínez (footballer) (born 1989), Honduran football midfielder
- Mario Martínez (baseball) (born 1989), professional baseball player
- Mario Martínez (boxer) (born 1965), former Mexican boxer