Marie-France is a French feminine given name. It may refer to :
- Marie-France Bazzo, Canadian broadcaster
- Marie-France Beaufils (born 1946), member of the Senate of France
- Marie-France Dubreuil (born 1974), Canadian ice dancer
- Marie-France Dufour (1949–1990), French singer
- Marie-France Garcia (born 1946), French singer and actress
- Marie-France Gaite (1941–1968), French singer
- Marie-France Hirigoyen (born 1949), French psychiatrist, psychoanalyst and psychotherapist
- Marie-France Larouche (born 1980), Canadian curler
- Marie-France Mignal (born 1940), French actress
- Marie-France Pisier (born 1944), French actress
- Marie-France Plumer (born 1943), French actress
- Marie-France Stirbois (1944–2006), French National Front politician
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