Marie-Claude is a moderately common French female given name. It may refer to:
- Marie-Claude Bourbonnais, Canadian model
- Marie-Claude Bakkal-Lagarde, French archaeologist
- Marie-Claude Beaud, the current director of the Mudam
- Marie-Claude Bompart, French politician with MPF
- Marie-Claude Jarrot, French politician with Union for a Popular Movement
- Marie-Claude Guigue, French historian
- Marie-Claude Monchaux, French children's book writer and illustrator
- Marie-Claude Pietragalla, French dancer and choreographer
- Marie-Claude Treilhou, French film director
- Marie-Claude Vaillant-Couturier, French resistance member
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