Mansoor Khan, son of film maker Nasir Hussain, made his directorial debut with Qayamat Se Qayamat Tak (1988) which launched the career of his cousin Aamir Khan. The film, a soft Romeo-Juliet inspired romantic drama, was a huge success. Coming towards the end of a decade dominated by action-oriented films, Mansoor Khan's directorial debut paved the way back for the musical romantic genre in Bollywood. The film made many careers: Aamir Khan, Juhi Chawla, Udit Narayan, Alka Yagnik and Anand-Milind.
He followed this success four years later with Jo Jeeta Wohi Sikander (1992). Mansoor Khan's last two films, Akele Hum Akele Tum (1995) and Josh (2000), were moderately successful. Both movies, the first an almost identical screenplay to Kramer vs. Kramer and the other an adaptation of West Side Story were outside productions with Mansoor just being a director. Josh was the only film out of all the films he directed that did not star Aamir Khan but instead had Shah Rukh Khan in the lead.
Mansoor Khan attended several engineering colleges only to drop out and later pursued his career in Bollywood. He attended some of the very well known colleges like Sri Venkateswara College, Delhi, Cornell, M.I.T. . Mansoor Khan's films have a soft human touch to them. A common thread running through all his films, apart from the long titles that is, is the theme of father-son relationship. Mansoor also has a good ear for music, and in the tradition of his father, the music in his films has always been highly appreciated.His films albums have received wins/nominations at major award function and became very popular amongst the audience. Alongside Karan Johar, is the only director/producer who has all hit films to his name.
Currently he has no plans to direct any other film. He is now settled in Coonoor, Tamil Nadu where he indulges in farming and other social causes.
He has made a comeback albeit as a producer and has co-produced the movie Jaane Tu Ya Jaane Na along with Aamir Khan. The movie, released on 4 July 2008, marked debut of Aamir Khan's nephew Imran Khan (actor).