Manderscheid can refer to:
- Manderscheid, Bernkastel-Wittlich, a town in the district Bernkastel-Wittlich, Rhineland-Palatinate, Germany.
- Manderscheid, Bitburg-Prüm a village in the district Bitburg-Prüm, Rhineland-Palatinate, Germany, part of the Verbandsgemeinde Arzfeld.
- the Counts of Manderscheid and the historical county of Manderscheid, centered on Manderscheid, Bernkastel-Wittlich.