Malate Dehydrogenase 2

Malate Dehydrogenase 2

Identifiers Symbols MDH2; M-MDH; MDH; MGC:3559; MOR1 External IDs OMIM: 154100 MGI: 97050 HomoloGene: 55938 ChEMBL: 5917 GeneCards: MDH2 Gene EC number 1.1.1.37

Gene Ontology
Molecular function	• L-malate dehydrogenase activity • protein self-association • malate dehydrogenase (NADP+) activity
Cellular component	• nucleus • nucleolus • mitochondrion • mitochondrial inner membrane • mitochondrial matrix • plasma membrane
Biological process	• carbohydrate metabolic process • glucose metabolic process • gluconeogenesis • tricarboxylic acid cycle • oxaloacetate metabolic process • malate metabolic process • internal protein amino acid acetylation • NADH metabolic process • cellular carbohydrate metabolic process • small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4191 17448 Ensembl ENSG00000146701 ENSMUSG00000019179 UniProt P40926 P08249 RefSeq (mRNA) NM_005918 NM_008617 RefSeq (protein) NP_005909 NP_032643 Location (UCSC) Chr 7:
75.68 – 75.7 Mb Chr 5:
135.78 – 135.79 Mb PubMed search

Malate dehydrogenase 2, NAD (mitochondrial), also known as MDH2, is a protein which in humans is encoded by the MDH2 gene.

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.