Cast
- Paul Reiser (Paul Buchman)
- Helen Hunt (Jamie Stemple Buchman)
- Anne Ramsay (Lisa Stemple)
- Leila Kenzle (Fran Devanow)
- Richard Kind (Dr. Mark Devanow)
- John Pankow (Ira Buchman)
- Maui (Murray the Dog)
- Cynthia Harris (Sylvia Buchman)
- Louis Zorich (Burt Buchman)
- Robin Bartlett (Debbie Buchman)
- Alyssa and Justin Baric in Season Six; later Carter and Madison Gayle (Mabel Buchman)
- Tommy Hinkley (Jay Selby, Paul's college friend who was a constant visitor at the Buchman apartment in the first episodes and was soon written out)
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