Mad1

Mad1

Identifiers Symbols MAD1L1; MAD1; PIG9; TP53I9; TXBP181 External IDs OMIM: 602686 MGI: 1341857 HomoloGene: 74500 GeneCards: MAD1L1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• kinetochore • condensed chromosome kinetochore • nucleus • nuclear pore • cytoplasm • mitochondrion • centrosome • spindle • cytosol • actin cytoskeleton
Biological process	• cell cycle checkpoint • M phase of mitotic cell cycle • mitotic metaphase • mitotic anaphase • mitotic telophase • mitotic prometaphase • mitotic cell cycle • mitotic cell cycle checkpoint • mitotic cell cycle spindle assembly checkpoint • cell division
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8379 17120 Ensembl ENSG00000002822 ENSMUSG00000029554 UniProt Q9Y6D9 Q9WTX8 RefSeq (mRNA) NM_001013836.1 NM_010752.3 RefSeq (protein) NP_001013858.1 NP_034882.2 Location (UCSC) Chr 7:
1.86 – 2.27 Mb Chr 5:
140.01 – 140.32 Mb PubMed search

Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.

MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes.

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.