MACE (acronym)
- Media Archive for Central England, a public sector regional film archive that collects, preserves and provides access to moving image materials
- MACE (codec), (Macintosh Audio Compression and Expansion) an audio encoding system
- Mar Athanasius College of Engineering, an Indian engineering college
- Malone antegrade continence enema
- MACE (gaming convention), Mid-Atlantic Convention Expo gaming convention
- Metropolitan Architectural Consortium for Education
- Major Adverse Cardiac Event: criterion for evaluating cardiac treatments such as angioplasty.
- M.A.C.E. Music, American record label
- Models And Counter-Examples a computer software for model generation
- Mesosphere and Climate Experiment, an atmospheric remote-sensing project proposed for the International Space Station
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