Notable People: MacDonald Surname
- Born after 1400
- John of Islay, Earl of Ross (1434–1503), or "John MacDonald", Scottish ruler, Fourth Lord of the Isles and Chief of the Highland Clan Donald
- Born after 1700
- Jacques MacDonald (1765–1840), French Duke of Tarento and Marshal of the Empire under Napoleon I (2nd generation French; father was Scottish)
- John MacDonald of Garth, (1771-18660, early partner in the North West Company
- John Small MacDonald (c.1791–1849), Canadian businessman and provincial politician
- Born after 1800
- A. B. MacDonald, American journalist
- Claude Maxwell MacDonald (1852–1915), British soldier and diplomat
- George MacDonald (1824–1905), Scottish-English author, poet, and Christian minister
- Hector MacDonald (1853–1903), Scottish Major-General of the British Army under Lord Kitchener
- John Alexander Macdonald (1815–1891), first Prime minister of Canada
- John L. MacDonald (1838–1903), Scottish-American national politician
- Pirie MacDonald (1867–1942), American portrait photographer
- Ramsay MacDonald (1866–1937), Scottish politician, twice Prime Minister of the United Kingdom (son of "Macdonald" father and "Ramsay" mother, registered at birth as "James McDonald Ramsay")
- Ranald MacDonald (1834–1894), Scottish-Chinook educator. First man to teach the English language in Japan
- William Josiah MacDonald (1873–1946), American lawyer and national politician
- Born after 1900
- Jeanette MacDonald (1903–1965), American singer and actress
- John MacDonald (rower) (1908–1982), New Zealand rower
- Ian MacDonald (actor) (1914–1978), American actor and director during the 1940s and 1960s
- Ross Macdonald (1915–1983), pseudonym of the American-Canadian writer Kenneth Millar
- John D. MacDonald (1916–1986), American novelist
- Charles B. MacDonald (1922–1990), American World War II soldier and military historian
- Flora MacDonald (born 1926), Canadian politician
- Peter MacDonald (Navajo leader) (born 1928) former chairman of the Navajo Nation
- Jeffrey R. MacDonald (born 1943), American murderer
- Kevin B. MacDonald (born 1944), American psychology academic
- John MacDonald (Canadian musician) (born 1948), Canadian musician of the French horn (current residence, Germany)
- Born after 1950
- Alan MacDonald (rugby union) (born 1985), Scottish rugby union player
- Andrew McDonald (water polo) (born 1955), American water polo player
- Ann-Marie MacDonald (born 1958), Canadian playwright, novelist, actor and broadcast journalist (born in West Germany to Canadian military parents)
- Garry MacDonald, English footballer
- Heidi MacDonald, American comic book editor and comics critic
- Jason MacDonald (born 1975), Canadian Mixed martial artist
- Kevin MacDonald (footballer) (born 1960), Scottish footballer
- Kirk MacDonald (ice hockey), Canadian ice hockey player
- Kirk MacDonald (politician), member of the Legislative Assembly of New Brunswick
- Mike MacDonald (born 1954), Canadian comedian and actor
- Mike MacDonald (born 1980), American rugby union player
- Roddie MacDonald (born 1954), Scottish footballer
- Roddy (R.S.) MacDonald, Scottish-Australian Pipe Major and composer (26 year residence in England)
- Rory MacDonald, Canadian professional mixed martial artist currently fighting in the UFC.
- Shaun MacDonald (born 1988), Welsh footballer
- William J. MacDonald (writer and producer), American television writer and producer
- Andrew Duck MacDonald, American heavy metal/hard rock guitarist
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