LHCGR Abnormalities
Loss-of-function mutations in females can lead to infertility. In 46, XY individuals severe inactivation can cause male pseudohermaphroditism, as fetal Leydig cells during may not respond and induce masculinization. Less severe inactivation can result in hypospadias or a micropenis.
Read more about this topic: Luteinizing Hormone/choriogonadotropin Receptor