LRG may stand for:
- Luminous red galaxy
- Lairg: LRG is the National Rail code for Lairg railway station, Scotland.
- Large: Extended Cylinder-head-sector, a mode of disk addressing. The abbreviation LRG is derived from "large mode", which is a term used by some computer BIOSes to refer to this method of addressing a disk.
- Lateral rotator group, a collection of external hip rotators in the human body
- Life Raft Group, an international gastrointestinal stromal tumor (GIST) patient support organization that focuses on patient support, advocacy, research, education and trial surveillance.
- Lifted Research Group, urban clothing line.
- Locus Reference Genomic, DNA sequence format
- LRG University of Applied Sciences, a Swiss private university with a famous hotel management program
- Ludlow Research Group, an association of professional geologists with research interests in the Silurian, founded in 1951 to provide a focus for the diverse projects then underway and still providing a valuable forum for the exchange and standardisation of nomenclature and stratigraphy