General
- Justino Lopes (October 17, 1930 - November 16, 1991) Portuguese, St Jorge Island, Moved to USA.
- Maria do Couto Maia Lopes (1890-2005) Portuguese supercentenarian.
- Fernão Lopes (c.1380–1459), Portuguese royal chronicler.
- Fernão Lopes (died 1545), Portuguese sailor and first inhabitant of the island of Saint Helena.
- Gregório Lopes (c.1490–1550), Portuguese painter.
- Cristóvão Lopes (c.1516–1594), Portuguese painter.
- Sir Manasseh Masseh Lopes, 1st Baronet (1755–1831), British Member of Parliament.
- Sir Ralph Lopes, 2nd Baronet (born "Ralph Franco" 1788–1854), British Member of Parliament
- Sir Massey Lopes, 3rd Baronet (born "Massey Franco" 1818–1908), British Member of Parliament
- Henry Lopes, 1st Baron Roborough (1859–1938), British Member of Parliament.
- Francisco Craveiro Lopes (1894–1960), Portuguese politician and military.
- Manuel Lopes (barber) (before 1850–after 1870), United States barber and first Black resident of Seattle.
- Nei Lopes (born 1942), Brazilian musician.
- Manuel Lopes (1907–2005), Capeverdian writer.
- Martinho da Costa Lopes (1918–1991), East Timorese religious and political leader.
- Massey Lopes, 2nd Baron Roborough (1903–1992), British peer and officer of the British Army.
- Américo Lopes (born 1933), Portuguese footballer.
- Fernando Lopes (born 1935), Portuguese filmmaker.
- Carlos Lopes (born 1947), Portuguese long-distance athlete.
- Davey Lopes (born 1945), United States baseball player and manager.
- Luís Carlos Melo Lopes (born 1954), Brazilian footballer.
- Edson Lopes (born 1957), Brazilian musician.
- Rosaly Lopes (born 1957), Brazilian earth-scientist.
- Giulio Lopes (born 1959), Brazilian actor.
- Marcelo Gonçalves Costa Lopes (born 1966), Brazilian footballer.
- Júlio Lópes (born 1967), Brazilian swimmer.
- Wagner Lopes (born 1969); Japanese footballer.
- Alexandre Paes Lopes (born 1974), Brazilian footballer.
- Daniel Lopes (born 1976), German singer.
- Welington Nogueira Lopes (born 1979), Brazilian footballer.
- Ana Paula Lopes (born 1979), Brazilian singer.
- Carlos Eduardo Lopes (born 1980), Brazilian footballer.
- Patrick Fabíonn Lopes (born 1980), Brazilian footballer.
- Astolpho Junio Lopes (born 1983), Brazilian
- Leandro Lopes (born 1984), Brazilian
- Matheus Henrique do Carmo Lopes (born 1985), Brazilian
- Felipe Aliste Lopes (born 1987), Brazilian
- Ernando Rodrigues Lopes (born 1988), Brazilian
- Everton Lopes (born 1988), Brazilian
- Mateus Lopes (born 1972), Capeverdian
- Aniceto Guterres Lopes (born 1967), East Timorese
- Laura Lopes née Parker-Bowles (born 1978), British
- Osvaldo Lopes (born 1980), French
- Adelino Lopes (born 1976), Guinea-Bissaun
- Sufrim Lopes (born 1981), Guinea-Bissaun
- Cecilio Lopes (born 1979), Dutch
- António Bastos Lopes (born 1953), Portuguese
- Pedro Santana Lopes (born 1956), Portuguese
- Fátima Lopes (born 1965), Portuguese
- Tiago André Coelho Lopes (born 1989), Portuguese
- Lisa Lopes (1971–2002), United States
- Brian Lopes (born 1971), United States
- Danny Lopes (born 1982), United States
- Mécia Lopes de Haro (died 1270), Portuguese
- Henrique Lopes de Mendonça (1856–1931), Portuguese
- João Simões Lopes Neto (1865–1916), Brazilian
- Baltasar Lopes da Silva (1907–1989), Capeverdian
- Álvaro Lopes Cançado (1912–1984), Brazilian
- Antônio Lopes (born 1941), Brazilian
- Dirceu Lopes (born 1946), Brazilian
- Amílcar Lopes Cabral (1924–1973), Capeverdian and Guinea-Bissau Statesman.
- António Lopes Ribeiro (1908–1995), Portuguese
- Paulo José Lopes de Figueiredo (born 1972), Angolan
- Tim Lopes (1950–2002), Brazilian
- Roberto Lopes (born 1966), Brazilian
- Rinaldo Lopes Costa (born 1968), Brazilian
- Luciano Lopes de Souza (born 1974), Brazilian
- Marcelo Lopes de Faria (born 1976), Brazilian
- Fábio Lopes Alcântara (born 1977), Brazilian
- Fábio Deivison Lopes Maciel (born 1980), Brazilian
- Wesley Lopes da Silva (born 1980), Brazilian
- Almir Lopes de Luna (born 1982), Brazilian
- Carlos Michel Lopes Vargas (born 1982), Brazilian
- Roberto Lopes Nascimento (born 1983), Brazilian
- Leila Lopes (born 1986), Angolan Miss Universe 2011 winner.
- Wesley Lopes Beltrame (born 1987), Brazilian
- Neylor Lopes Gonçalves (born 1987), Brazilian
- Santinho Lopes Monteiro (born 1979), Dutch
- Valmiro Lopes Rocha (born 1981), Spanish
- Fernando Lopes-Graça (1906–1994), Portuguese
- Olga Lopes-Seale (born 1918), Barbadian
- Ephraim Lópes Pereira d'Aguilar, 2nd Baron d'Aguilar (1709–1832), British
- John Reginald Lopes Yarde-Buller, 3rd Baron Churston (1873–1930), British
- Oscar Lino Lopes Fernandes Braga (born 1931), Angolan
- Lopes Gonçalves, Portuguese explorer
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