Organizations
- LOC Architects, the Los Angeles based architecture firm
- Library of Congress, the national library of the United States
- LeMoyne-Owen College, a historically black college located in Memphis, Tennessee
- Lyric Opera of Chicago
- Liga Obrera Comunista, or Communist Workers League (Spain), a Trotskyist group in Spain active from 1976–1990
- Loc Publishing, an imprint of the German group VDM Publishing devoted to the reproduction of Wikipedia content
- Love Of Crips, or League Of Crips, a gang abbreviation
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