Middleweight
| Name | Reign period | No. of successful defenses |
| Dick Tiger | August 10, 1963 – December 7, 1963 | 0 |
| Joey Giardello | December 7, 1963 – October 21, 1965 | 1 |
| Dick Tiger | October 21, 1965 – April 25, 1966 | 0 |
| Emile Griffith | April 25, 1966 – April 17, 1967 | 2 |
| Nino Benvenuti | March 4, 1968 – November 7, 1970 | 4 |
| Carlos Monzón | November 7, 1970 – February 9, 1974 (stripped) | 9 |
| Rodrigo Valdéz def. Bennie Briscoe |
May 25, 1974 – June 26, 1976 | 4 |
| Carlos Monzón | June 26, 1976 – August 1977 (retired) | 1 |
| Rodrigo Valdéz def. Bennie Briscoe |
November 5, 1977 – April 22, 1978 | 0 |
| Hugo Corro | April 22, 1978 – June 30, 1979 | 2 |
| Vito Antuofermo | June 30, 1979 – March 16, 1980 | 1 |
| Alan Minter | March 16, 1980 – September 27, 1980 | 1 |
| Marvelous Marvin Hagler | September 27, 1980 – April 6, 1987 | 12 |
| Sugar Ray Leonard | April 6, 1987 – May 27, 1987 (retired) | 0 |
| Thomas Hearns def. Juan Roldán |
October 29, 1987 – June 6, 1988 | 0 |
| Iran Barkley | June 6, 1988 – February 24, 1989 | 0 |
| Roberto Durán | February 24, 1989 – December, 1989 (vacated) | 0 |
| Julian Jackson def. Herol Graham |
November 24, 1990 – May 8, 1993 | 4 |
| Gerald McClellan | May 8, 1993 – May 7, 1994 (vacated) | 3 |
| Julian Jackson def. Agostino Cardamone |
March 17, 1995 – August 19, 1995 | 0 |
| Quincy Taylor | August 19, 1995 – March 16, 1996 | 0 |
| Keith Holmes | March 16, 1996 – May 2, 1998 | 2 |
| Hassine Cherifi | May 2, 1998 – April 24, 1999 | 0 |
| Keith Holmes | April 24, 1999 – April 14, 2001 | 2 |
| Bernard Hopkins | April 14, 2001 – July 16, 2005 | 7 |
| Jermain Taylor | July 16, 2005 – September 29, 2007 | 4 |
| Kelly Pavlik | September 29, 2007 – April 17, 2010 | 3 |
| Sergio Martínez | April 17, 2010 – January 17, 2011 (stripped) | 1 |
| Sebastian Zbik (Elevated from interim status) |
January 17, 2011 – June 4, 2011 | 0 |
| Julio César Chávez, Jr. | June 4, 2011 – September 15, 2012 | 3 |
| Sergio Martínez | September 15, 2012 – Present |
Read more about this topic: List Of WBC World Champions