Lightweight
| Name | Reign period | No. of successful defenses |
| Carlos Ortíz | February 14, 1963 – April 10, 1965 | 3 |
| Ismael Laguna | April 10, 1965 – November 13, 1965 | 0 |
| Carlos Ortíz | November 13, 1965 – June 29, 1968 | 5 |
| Carlos Cruz | June 29, 1968 – February 18, 1969 | 1 |
| Mando Ramos | February 18, 1969 – March 3, 1970 | 1 |
| Ismael Laguna | March 3, 1970 – September 15, 1970 (stripped) | 1 |
| Ken Buchanan def. Rubén Navarro |
February 12, 1971 – June 25, 1971 (stripped) | 0 |
| Pedro Carrasco def. Mando Ramos |
November 5, 1971 – February 18, 1972 | 0 |
| Mando Ramos | February 18, 1972 – September 15, 1972 | 1 |
| Chango Carmona | September 15, 1972 – November 10, 1972 | 0 |
| Rodolfo González | November 10, 1972 – April 11, 1974 | 2 |
| Guts Ishimatsu | April 11, 1974 – May 8, 1976 | 5 |
| Esteban De Jesús | May 8, 1976 – January 21, 1978 | 3 |
| Roberto Durán | January 21, 1978 – January, 1979 (vacated) | 0 |
| Jim Watt def. Alfredo Pitalua |
April 17, 1979 – June 20, 1981 | 4 |
| Alexis Argüello | June 20, 1981 – 1983 (vacated) | 4 |
| Edwin Rosario def. José Luis Ramírez |
May 1, 1983 – November 3, 1984 | 2 |
| José Luis Ramírez | November 3, 1984 – August 10, 1985 | 0 |
| Héctor Camacho | August 10, 1985 – 1987 (vacated) | 2 |
| José Luis Ramírez def. Terrence Alli |
July 19, 1987 – October 29, 1988 | 2 |
| Julio César Chávez | October 29, 1988 – 1989 (vacated) | 0 |
| Pernell Whitaker def. José Luis Ramírez |
August 20, 1989 – 1992 (vacated) | 6 |
| Miguel Ángel González def. Wilfrido Rocha |
August 24, 1992 – August 19, 1995 (vacated) | 10 |
| Jean Baptiste Mendy def. Lamar Murphy |
April 20, 1996 – March 1, 1997 | 0 |
| Stevie Johnston | March 1, 1997 – June 13, 1998 | 3 |
| César Bazán | June 13, 1998 – February 27, 1999 | 2 |
| Stevie Johnston | February 27, 1999 – June 17, 2000 | 4 |
| José Luis Castillo | June 17, 2000 – April 20, 2002 | 3 |
| Floyd Mayweather, Jr. | April 20, 2002 – May 22, 2004 (vacated) | 3 |
| José Luis Castillo def. Juan Lazcano |
June 5, 2004 – May 7, 2005 | 2 |
| Diego Corrales | May 7, 2005 – October 7, 2006 (stripped) | 0 |
| Joel Casamayor def. Corrales, who was stripped of his title |
October 7, 2006 – February 1, 2007 (stripped) | 0 |
| David Díaz (Elevated from interim status) |
February 1, 2007 – June 28, 2008 | 1 |
| Manny Pacquiao | June 28, 2008 – February 24, 2009 (vacated) | 1 |
| Edwin Valero def. Antonio Pitalua |
April 4, 2009 – February 9, 2010 (vacated) | 2 |
| Humberto Soto def. David Díaz |
March 13, 2010 – July 1, 2011 (vacated) | 4 |
| Antonio DeMarco def. Jorge Linares |
October 15, 2011 – Present | 2 |
Read more about this topic: List Of WBC World Champions