- Carl Franz Bally (1821–1899), founder of the Bally Shoe company
- Ernesto Bertarelli (born 1965), entrepreneur, founder of Team Alinghi
- Daniel Borel (born 1950), founder of Logitech
- Abraham-Louis Breguet (1747–1823), watchmaker
- François-Louis Cailler (1796–1852), chocolatier
- Louis Chevrolet (1878–1941), automobile engineer, founder of Chevrolet
- Gottlieb Duttweiler (1888–1962), entrepreneur, founder of Migros
- Alfred Escher (1819–1882), statesman, businessman and railway constructor
- Hans Conrad Escher von der Linth (1767–1823), architect of the Lint melioration
- Louis Favre (1826–1879), engineer of the Gotthard tunnel
- Nessim Gaon (born 1922), financier, founder of the Noga company
- Adolf Guyer-Zeller (1839–1899), railway entrepreneur
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- Nicolas Hayek (1928–2010), entrepreneur, chairman, Swatch Group
- Baron Jean-Conrad Hottinguer (1764–1841), banker
- Jürg Marquard (born 1945), magazine publisher
- Henri Nestlé (1814–1890), founder of Nestlé S.A.
- Daniel Peter (1836–1919), inventor of milk chocolate
- Georges Edouard Piaget (1855–1931), watchmaker
- Beat Fischer von Reichenbach (1641–1698), held postal monopoly in Berne
- Werner Reinhart (1884–1951), industrialist, philanthropist, music and literature patron
- Daniel Jean-Richard (1665–1741), watchmaker
- Philippe Suchard (1797–1884), chocolatier
- Ernst Thomke (born 1939 in Biel/Bienne, turnaround manager, e.g. Swatch
- Daniel Vasella (born 1953), chairman
- William de Vigier (1912–2003), entrepreneur
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