S
- Michele Scarabelli
- Alan Scarfe
- Robert Schenkkan
- Vincent Schiavelli
- Dwight Schultz
- Judson Scott
- Kathryn Leigh Scott
- Howie Seago
- Carolyn Seymour
- Jack Sheldon
- Mark Allen Shepherd
- W. Morgan Sheppard
- Brandi Sherwood
- Armin Shimerman
- Dan Shor
- Alexander Siddig
- Esteban Siller (Latin American dub: additional voices)
- Jean Simmons
- Madge Sinclair
- Marina Sirtis
- James Sloyan
- Norman Snow
- Michael Snyder
- Paul Sorvino
- Dana Sparks
- Brent Spiner
- Skip Stellrecht
- Stephen Gregory (actor)
- Jon Paul Steuer
- Patrick Stewart
- David Ogden Stiers
- Carel Struycken
- Jandi Swanson
- Joel Swetow
Read more about this topic: List Of Star Trek: The Next Generation Cast Members